How cystic fibrosis can affect fertility and reproductive health?

The worldwide count of cystitis fibrosis is more than 80,000 which is a major concern for adults. Be it men or women, both of the individual’s reproductive health gets impacted. Dr. Sumita Sofat, one of the well-known gynecologist in Punjab will give ultimate care to you for this condition. Due to cystic fibrosis (CF), even the sex hormone levels are produced normally in the body like:

• Estrogen

• Progesterone

• Testosterone

One of the best IVF Centre in Punjab, Sofat Infertility and Women Care Centre, you will get the treatment plan to improve your conception chances. Cystic fibrosis leads to genetic mutations which is the major reason that both men and women are diagnosed with this condition.

Treatment for men with Cystic fibrosis

Due to cystic fibrosis, fertility and reproductive health are affected. The studies have shown that 98% of men with cystic fibrosis are infertile. In this case, the body creates sperm but it can get:

• Missing

• Blocked

In this case, the sperm is not mixed with the semen. Keeping that aside, it does not impact performance and sexual desire in any manner. Cystic fibrosis increases the fluid accumulation in the testes which impacts the way it works. There are high chances that the sperm are not produced in the desired amount or there is no mature sperm.

Possible treatment options for men

The fertility doctor will perform a treatment plan through which sperm is taken out from the body and then fertilized along with an egg. The doctor will perform the sperm extraction through the following:

• Micro Epididymal sperm aspiration (MESA)

• Percutaneous epididymal sperm aspiration (PESA)

• Testicular sperm extraction (TESE)

Whichever sperm extraction method seems best in your situation the doctor will use that. Once the sperm is collected then IVF (In-Vitro-Fertilization) is performed.

Treatment for women with Cystic Fibrosis

Studies have shown that both males and females are affected at the same rate. Cystic fibrosis does not cause any evident change in the physical structure of the female reproductive organs. The mucus covering the cervix & vagina is thick which creates difficulty for sperm to reach the egg & then begin the process of fertilization.

It is also possible that women diagnosed with cystic fibrosis might not ovulate as the lung, weight, and nutrition issues are there.

Possible treatment options for women

Due to the advanced and innovative methods, the number of women who can conceive with cystic fibrosis is increasing. The treatment options of:

• Insemination

• In-Vitro-Fertilization (IVF)

Are you family planning?

Are you trying to conceive? Well! A healthier approach, living a better quality of life, and getting yourself the right treatment plan on time is important. Doing so will address your health issues in a better manner and your chances of conception will improve manifolds. Schedule your initial consultation with Dr. Sumita Sofat and get the best treatment plan & even get an understanding of what you need to do.

Pills are the most commonly used way of birth control. Women prefer pills after having unprotected sex because they take it as a simple and easy way to get to escape from unwanted pregnancy. No woman is aware of the negative effects associated with these pills. Before understanding the side effects of these birth control pills it is important to understand the working of them.

How do pills work for birth control?

• These pills prevent you from ovulation by interfering with the communication of brain and ovaries as a result of which hypothalamic pituitary ovarian axis get disturbed and you could not ovulate

• Mucus pattern reflects about women fertility window and these pills prevent you from producing the cervical mucus so due to lack of mucus men sperm cannot go near to egg so prevent you from getting pregnant.

• Pills also prevent the fertilized egg to the implant by preventing the uterine lining from fully developing.

In simple words, we can say that these pills enter into the endocrine system and disturb it to escape you from getting pregnant.

But most of the women are oblivion about the side effects of these pills if taken for a longer time. Following are some facts that will prove that hormone contraceptive are not a good choice for prolonged use.

1. The decline in your sex drive

These pills shut down the ovaries so prevent them from producing sex hormones so shut down the production of testosterone so its level gets lower by 3 to 4 times than the level they would have been so due to lower level of testosterone you sex drive also get lower. As long as you will use pills your sex level will get lower due to decreasing level of testosterone.

2. Shrinking of the clitoris so lead to painful sex

Prolonged use of pills reduces the vascularization of your clitoris and thickness of vulvar tissues. Even these pills also lead to painful sex as due to the shrinking of clitoris then there are chances of messing with the tissues around the vaginal opening so you feel pain during intercourse.

3. Depression and anxiety

Due to decrease level of testosterone level as a result of using pills, women can get depression as testosterone has an inverse relationship with depression so with a lower level of it the risk of depression increases. Moreover, pills also reduce Vitamin B6 metabolism so also lead to a risk of depression.

Even women complaint about the effects like lethargic, sad stress and other emotional attacks.

4. Increased risk of cancer

Long-term use of pills is associated with the deficiency of folic acid so it can increase the risk of HPV infection hence you can be caught by cervical cancer.

5. Difficult to get fertile again

Long-term use of pills disturbs the hormone level of your body so if you ever think about getting pregnant then it may take longer to get a normal menstrual cycle and fertility.

6. Your fertility get changed

It is the biggest myth that fertility never changes with age but the fact is that fertility gets reduced with the age so if you are getting pills then your fertility level also can change with the passage of time and age.

Perimenopause and Menopause are stages in a woman’s life following the fertile days of her life. The common question about menopause is whether a woman can still get pregnant during this phase or during perimenopause or past postmenopause.

The fact is yes, a woman can still get pregnant during these phases of her life, but it isn’t a guarantee in all cases. The reason why I say this is that these phases don’t manifest themselves overnight, but it takes, days, months, and years to enter each phase. So, you never know!

Perimenopause, Menopause, & Postmenopause: What Do These Terms Signify?

The woman’s reproductive cycle is certainly interesting and the deeper you go, you will find that several aspects work together to facilitate fertility. During a woman’s reproductive years, she will continue producing several hormones that include; Luteinizing hormone (LH), Estrogen, Progesterone, and Follicle stimulating hormone (FSH).

For ovulation to occur or pregnancy, these hormones must be in a normal range. This also brings us to the fact that not every woman who menstruates can ovulate, although, that is how it must be. As years go by, a woman’s fertility rate or pregnancy chances naturally decline and the where she stops ovulating is known as menopause.

The Perimenopause phase can be termed as a transitional phase in a woman’s life. This is generally when the ovaries begin producing fewer hormones; ‘estrogen & progesterone’, yet on the other hand, your  LH and FSH levels increase.

Hot flashes, night sweats, irregular periods, and rare ovulation are some of the symptoms to expect during this phase.

The Menopause phase, however, is a period when your LH and FSH levels remain high, while your estrogen and progesterone levels remain low. Initially, it may be hard for you to know that you are in your menopausal stage, but once you realize no periods for over a year, this means that you are in your menopausal phase.

During this phase, a woman can no longer ovulate or conceive a child. Most women enter their menopausal phase after the age of 40.

The Postmenopause phase is that period of life when you no longer need to take birth control measures to avoid pregnancy.

Is Pregnancy Possible?

As explained above, it is possible to get pregnant, but your odds fall by each stage. Natural conception is possible during the perimenopause, but largely not possible during menopause and postmenopause.

In case a woman desires to get pregnant, IVF treatment is an excellent alternative for conception. It should be noted that menopause is irreversible. A couple should plan accordingly to avoid conception troubles that escalate with age advancement.

Most of the women do not even know about their infertility until they came in front of their inability to conceive. When they fail to be mothers naturally then they think about infertility problem and consult with the doctor but their delay in identifying the infertility problem leads to the delayed diagnosis that can directly influence the treatment’ effectiveness so it is quite important to be aware of the infertility problem if you are having the same.

To help you to know about your inability to conceive in this post we will reveal some factors that are clear indications of infertility among females.

Not having regular periods

Abnormal and irregular periods are the clear indication for the problem in the reproductive system so one should not ignore if she is not having regular period after the adequate time period that is 28-32 days. If you are having irregularities in your periods and even missing periods then you must consult your doctor as it can be the symptom for PCOS. The only gynaecologist can help you to tell about the exact reason for irregularity in your periods that become the hindrance for your pregnancy.

Hormonal imbalance

Hormonal irregularities and disturbing level can adversely affect your reproductive system. PCOS is the hormonal imbalance which generally becomes the reason for irregular periods and disturbs the ovulation cycle apart from this hypothalamic dysfunction also affects the ovulation function and become the reason that disturbs the production of two hormones that are FSH and LH that are quite essential for timely release of mature eggs. This condition can be due to excessive and prolonged stress, fatigue or weight loss or gain.

These irregularities of hormones in the body can be identified by few signs of the body like facial hair growth, thinning hair, weight gain and even loss in sex drive.

Painful intercourse

Some women do not want to open up about their experience with their physical relations with their husbands so feel shy about it but your discussion can tell you that you are satisfied with your sex life. If you feel pain during sex than it is advisable to talk to your gynaecologist to understand about this symptom of female infertility.

If you are having any of above issues or all then it is not time to ignore yourself as the timely diagnosis of infertility problem and you can get the effective results of infertility issues and could become the biological mother.

Infertility is the major issue. With the passage of time, fertility will become the more complex process.

The reproductive abilities of the women are closely related to the eggs she produces. A woman usually produces the immature eggs. These eggs are produced at the time of the ovulation. The number of the eggs to be produced is decreased with the passage of the time.

Age is the thing that you cannot control but the fertility changes with the passage of the time. Fertility is at the peak level in the early and mid-twenties. IVF is the treatment that helps to attain the post of the parenthood in the infertile couples. The concept of late marriages and late family planning will lead to the failed level of conceptions. The limited number of the eggs will lead to the problem in the natural conception and IVF failures.

Consider IVF with Donor Egg

Egg donation is the most important treatment option for the couples who are not able to conceive with their own egg. In this case, egg donation plays an important role. You can refer to the best IVF centre in India so that you can get the high-quality eggs in order to produce the healthier embryos. This is the best method to achieve infertility and helps to conceive successfully. IVF increases the chances the fertility but the IVF with the donor eggs increases the chances of the fertility at the maximum level.

A Pelvic Inflammatory Disease (PID) is one of the leading causes of infertility in women. 2 in 10 women struggling with infertility are annually diagnosed with a PID or PID complications which cause the major inability of conception.

A pelvic inflammatory disease commonly affects women aged between 16 to 30.

What is a PID?

A PID is an infection that affects a woman’s reproductive system and it is mainly caused by STIs (Sexually Transmitted Diseases). STIs include Chlamydia, Gonorrhea or untreated Chronic Bacterial Vaginosis (BV), which isn’t sexually transmitted.

In addition, you can develop a PID or PID complications like infertility in case of;

• Having multiple sexual partners

• Having a partner with multiple sexual partners

• Frequent douching, which can spread the bacteria from one area of the reproductive system to another

• Using IUD, a contraceptive device. Some women suffer from a PID a few weeks after inserting the IUD.

• A history of a PID may also cause infertility cases

Fertility experts at the leading IVF centre in Abohar confirm that women who have sex before the age of 20 have to get examined by an experienced gynecologist to prevent the PID from affecting other parts of the reproductive system like the ovaries, uterus and the Fallopian tubes.

Symptoms of a PID

A PID almost has the same symptoms like most of the other fertility cases in women. Some of the symptoms include;

• Abdominal pain

• Heavy vaginal discharge with a bad odor

• Pain during sexual intercourse

• Fever and chills

• Painful urination

• Irregular periods

• Chronic pelvic pain

The following are some of the indicators that you may have a PID, but once you visit the fertility experts at the IVF centre in Batala, a blood test and an ultrasound will be performed to help the experts in their observations.

What is the impact of a PID on a women’s Fertility?

A prolonged PID infection that even goes without the right treatment has a 50% negative impact on a woman’s fertility health. Once the bacteria develop in the vagina, it will continue spreading to the endometrium, the ovaries, and the Fallopian tubes.

It should be noted that PIDs are some of the major causes of a blockage in the Fallopian tubes which automatically hinders conception.

A woman with a history of a PID has higher chances of suffering from an ectopic pregnancy.

It is vital that you treat the PID once you know that you have one to prevent infertility complications.

What should I do?

• A PID is treated with Antibiotics, but you must get a blood test and an ultrasound for the fertility expert to know what exactly is wrong.

• Much as you may be under treatment for a PID, it is better to abstain from sex even after the treatment is over to prevent recurrence.

• Let your partner attain treatment

Other Considerations

In case struggling with infertility or have a history of PID and worried about your conception chances, start on the following:

Fertility massage

It is usually self-massage to boost your fertility chances, meaning that you won’t need to incur any cost. You can attain tips of this exercise from our IVF centre in Balachaur.

• Diet

A fertility diet full of green leafy vegetables, legumes, proteins and organic poultry will help boost your fertility.

• Systematic Enzyme Therapy

This therapy will help eliminate toxins from the bloodstream and reduce inflammation.

• Physical exercises

An active body will reduce the effects of the PID. Running, walking, gyming or swimming will keep your body and muscles fit.

ERA Endometrial Receptivity Analysis

ERA Endometrial Receptivity Analysis is the diagnostic method that has been developed and patented in 2009. This method is used to check the woman’s endometrial receptivity from the molecular aspect. Era is the WOI (called window of implantation), used to increase the chances of the successful embryo transfer. This embryo transfer is done in the 19 to 21 days of the menstrual cycle of the fertile woman. If there is any kind of lack of the synchronization between the embryo ready for the implantation and endometrial receptivity, this the major cause of the implantation failure. This is the essential condition to assess the endometrial to determine the optimal day of the embryo transfer.

What is the Endometrial Receptivity Analysis used for?

ERA is used to access the information about the endometrial status and receptive gene profile at the time of biopsy. This analysis is used to check the personalized window of the implantation of each lady. These include the data about the personalized embryo transfer, synchronizing endometrial receptivity with a blastocyst and prepare it for the implantation.

The outcome of the test will reveal that whether the woman was receptive or not at the time of the sampling. If the woman is receptive, this shows that her window of the implantation falls on the day of the transfer at the time of the biopsy. The embryo will be transferred to the uterus during that time period.

If the woman is not receptive, then the procedure will be repeated with the computational predictor. Computational predictor will help you to estimate the woman’s personalized view of the implantation. This will help you to the successful transfer of the embryo with the subsequent cycle. This technique is known as Personalized Embryo transfer (PET). The best IVF centre in Amritsar will perform the ERA analysis accurately and completely.

Who is the ERA Endometrial Receptivity Analysis for?

ERA is performed on those patients who have repeat implantation failure but have good morphological quality.

This is also performed for those patients whose normal uterus and normal endometrial thickness is greater than the 6mm.

This test is also done with the patients who are having atrophic endometrial and never reaches their thickness at 6mm consistently.

This test is always recommended by the best IVF centre in Bhatinda. The result will be sent to the doctor directly. The report is not visible to the patient. The only doctor will help you to specify the whole procedure.

What are the advantages of the ERA Endometrial Receptivity Analysis?

This method provides the accurate results in detecting the gene expression profiles associated with the receptivity. This is based on the histological criteria. This method has the high degree of the sensitivity and there are not even slight significant molecular changes.

What technology is used with ERA?

Next-generation sequencing technology is used to correctly analysis the endometrial status. When it is used with the new and the improved predictor, its effectiveness of the diagnosis will be increased at the highest level. The best IVF centre in Barnala helps you to provide the more accurate results.